Two sample MR report
HOMER2_Interstitial Macrophages against finn-b-ASTHMA_ALLERG_EXMORE
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 5 | -0.0442940 | 0.2584496 | 0.8748302 |
| Weighted median | 5 | -0.0789951 | 0.0212968 | 0.0002079 |
| Inverse variance weighted | 5 | -0.0794830 | 0.0166029 | 0.0000017 |
| Simple mode | 5 | -0.0779314 | 0.0259845 | 0.0399754 |
| Weighted mode | 5 | -0.0776386 | 0.0266463 | 0.0435178 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 0.0432280 | 3 | 0.9976404 |
| Inverse variance weighted | 0.0618428 | 4 | 0.9995317 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0390365 | 0.2861161 | 0.9001178 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 8.73e-05 | 0 | TRUE | 0.3788166 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
